Research Type: Multiple Sites Cancer
Project Description
Up to 80% of cancer patients experience severe muscle wasting that limits treatment, decreases quality of life and reduces survival. Unfortunately, there are currently no effective treatments available. Muscle repair and maintenance requires specialized cells called fibro/adipogenic progenitors (FAPs) to coordinate other cells and direct healthy muscle repair. This project will use clinically relevant cancer and exercise models to examine the mechanisms by which exercise may help regulate FAPs to reduce muscle wasting. Dr De Lisio hopes these insights will improve treatment delivery, increase quality of life and improve survival in cancer patients.
